In this paper, we intend to discuss the main transformations of the profiles of employability and professionalisation of graduates when they have to face the labour market. Both international and national investigations reveal a significant accumulation of scientific knowledge, which attests the in-depth transformations of the objective and subjective conditions of the processes of professional transition in the majority of the advanced economies. In fact, in the last decades, the majority of the career paths of graduates has been presenting recurrent traits, such as: i) difficulties of access to the first job; ii) forced experiences of underemployment and unemployment; iii) danger of “overqualification” and less correspondence of the diploma to the job/profession; iv) competitive or superposed diplomas in the delimitation of the “professional act”; v) difficulties in developing a career and projection of future professionals; vi) biographical trajectories based on ruptures and/or educational and identity reconversions, among others. It is our intent to use some empirical evidence obtained from research projects lead by us in last years, namely: “Meintegra” (Integrate me), “Integration paths of graduates” and “The entrepreneurship potential”.